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KAP1 targets actively transcribed genomic loci to exert pleomorphic effects on RNA polymerase II activity

KAP1 (KRAB-associated protein 1) is best known as a co-repressor responsible for inducing heterochromatin formation, notably at transposable elements. However, it has also been observed to bind the transcription start site of actively expressed genes. To address this paradox, we characterized the pr...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Philos Trans R Soc Lond B Biol Sci
Main Authors: Kauzlaric, Annamaria, Jang, Suk Min, Morchikh, Mehdi, Cassano, Marco, Planet, Evarist, Benkirane, Monsef, Trono, Didier
פורמט: Artigo
שפה:Inglês
יצא לאור: The Royal Society 2020
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC7061982/
https://ncbi.nlm.nih.gov/pubmed/32068487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rstb.2019.0334
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