1,25-Dihydroxyvitamin D insufficiency accelerates age-related bone loss by increasing oxidative stress and cell senescence

We investigated the role of insufficiency of the active form of vitamin D, 1,25-dihydroxyvitamin D [1,25(OH)(2)D] in age-related bone loss. We employed mice with heterozygous deletion of Cyp27b1, the gene encoding the enzyme that synthesizes 1,25(OH)(2)D, as a model for 1,25(OH)(2)D insufficiency an...

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Veröffentlicht in:Am J Transl Res
Hauptverfasser: Qiao, Wanxin, Yu, Shuxiang, Sun, Haijian, Chen, Lulu, Wang, Rong, Wu, Xuan, Goltzman, David, Miao, Dengshun
Format: Artigo
Sprache:Inglês
Veröffentlicht: e-Century Publishing Corporation 2020
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7061846/
https://ncbi.nlm.nih.gov/pubmed/32194899
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