Antidepressant-Like Effects and Cognitive Enhancement of Coadministration of Chaihu Shugan San and Fluoxetine: Dependent on the BDNF-ERK-CREB Signaling Pathway in the Hippocampus and Frontal Cortex

BACKGROUND: Fluoxetine (FLU) is the first-line and widely used medication for depression; however, FLU treatment is almost ineffective in 30%-40% of patients with depression. In addition, there are some problems in FLU treatment, such as delayed efficacy, large side effects, and poor tolerance. Chai...

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Publicat a:Biomed Res Int
Autors principals: Yan, Lijing, Xu, Xia, He, Zhenyu, Wang, Sheng, Zhao, Linlin, Qiu, Juan, Wang, Dongsheng, Gong, Zhicheng, Qiu, Xinjian, Huang, Huiyong
Format: Artigo
Idioma:Inglês
Publicat: Hindawi 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7060874/
https://ncbi.nlm.nih.gov/pubmed/32185198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2020/2794263
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