GDF11 promotes osteogenesis as opposed to MSTN, and follistatin, a MSTN/GDF11 inhibitor, increases muscle mass but weakens bone

Growth and differentiation factor 11 (GDF11) and myostatin (MSTN) are closely related transforming growth factor β (TGF-β) family members, but their biological functions are quite distinct. While MSTN has been widely shown to inhibit muscle growth, GDF11 regulates skeletal patterning and organ devel...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Suh, Joonho, Kim, Na-Kyung, Lee, Seung-Hoon, Eom, Je-Hyun, Lee, Youngkyun, Park, Joo-Cheol, Woo, Kyung Mi, Baek, Jeong-Hwa, Kim, Jung-Eun, Ryoo, Hyun-Mo, Lee, Se-Jin, Lee, Yun-Sil
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2020
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7060712/
https://ncbi.nlm.nih.gov/pubmed/32071240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1916034117
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