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The LC8-RavP ensemble structure evinces a role for LC8 in regulating Lyssavirus polymerase functionality

The rabies and Ebola viruses recruit the highly conserved host protein LC8 for their own reproductive success. In vivo knockouts of the LC8 recognition motif within the rabies virus phosphoprotein (RavP) result in completely non-lethal viral infections. In this work, we examine the molecular role LC...

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Detalhes bibliográficos
Publicado no:J Mol Biol
Main Authors: Jespersen, Nathan E., Leyrat, Cedric, Gérard, Francine C., Bourhis, Jean-Marie, Blondel, Danielle, Jamin, Marc, Barbar, Elisar
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7060403/
https://ncbi.nlm.nih.gov/pubmed/31634467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2019.10.011
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