Anti-PD-1 immunotherapy leads to tuberculosis reactivation via dysregulation of TNF-α

Previously, we developed a 3-dimensional cell culture model of human tuberculosis (TB) and demonstrated its potential to interrogate the host-pathogen interaction (Tezera et al., 2017a). Here, we use the model to investigate mechanisms whereby immune checkpoint therapy for cancer paradoxically activ...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:eLife
Egile Nagusiak: Tezera, Liku B, Bielecka, Magdalena K, Ogongo, Paul, Walker, Naomi F, Ellis, Matthew, Garay-Baquero, Diana J, Thomas, Kristian, Reichmann, Michaela T, Johnston, David A, Wilkinson, Katalin Andrea, Ahmed, Mohamed, Jogai, Sanjay, Jayasinghe, Suwan N, Wilkinson, Robert J, Mansour, Salah, Thomas, Gareth J, Ottensmeier, Christian H, Leslie, Alasdair, Elkington, Paul T
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: eLife Sciences Publications, Ltd 2020
Gaiak:
Immunology and Inflammation
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7058383/
https://ncbi.nlm.nih.gov/pubmed/32091388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.52668
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