Vascular progenitors generated from tankyrase inhibitor-regulated naïve diabetic human iPSC potentiate efficient revascularization of ischemic retina

Here, we report that the functionality of vascular progenitors (VP) generated from normal and disease-primed conventional human induced pluripotent stem cells (hiPSC) can be significantly improved by reversion to a tankyrase inhibitor-regulated human naïve epiblast-like pluripotent state. Naïve diab...

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Publicat a:Nat Commun
Autors principals: Park, Tea Soon, Zimmerlin, Ludovic, Evans-Moses, Rebecca, Thomas, Justin, Huo, Jeffrey S., Kanherkar, Riya, He, Alice, Ruzgar, Nensi, Grebe, Rhonda, Bhutto, Imran, Barbato, Michael, Koldobskiy, Michael A., Lutty, Gerard, Zambidis, Elias T.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7058090/
https://ncbi.nlm.nih.gov/pubmed/32139672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14764-5
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