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Recapitulating T cell infiltration in 3D psoriatic skin models for patient-specific drug testing

Drug screening studies for inflammatory skin diseases are currently performed using model systems that only partially recapitulate human diseased skin. Here, we developed a new strategy to incorporate T cells into human 3D skin constructs (HSCs), which enabled us to closely monitor and quantitate T...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Shin, Jung U, Abaci, Hasan E., Herron, Lauren, Guo, Zongyou, Sallee, Brigitte, Pappalardo, Alberto, Jackow, Joanna, Wang, Eddy Hsi Chun, Doucet, Yanne, Christiano, Angela M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7057979/
https://ncbi.nlm.nih.gov/pubmed/32139717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-60275-0
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