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Early-life inhalant allergen exposure, filaggrin genotype, and the development of sensitization from infancy to adolescence

BACKGROUND: We hypothesized that filaggrin (FLG) loss-of-function mutations modify the effect of allergen exposure on the development of allergic sensitization. OBJECTIVE: We sought to determine whether early-life exposure to inhalant allergens increases the risk of specific sensitization and whethe...

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Pubblicato in:J Allergy Clin Immunol
Autori principali: Simpson, Angela, Brough, Helen A., Haider, Sadia, Belgrave, Danielle, Murray, Clare S., Custovic, Adnan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Mosby 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7057264/
https://ncbi.nlm.nih.gov/pubmed/31629803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2019.08.041
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