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MicroRNA dysregulation and multi-targeted therapy for cancer treatment
We established that loss of miR-15a/16-1 genes on chromosome 13q14 is the most common alteration in Chronic Lymphocytic Leukemia (CLL) and that miR-15/16 are crucial negative regulator of BCL-2, an antiapoptotic gene overexpressed in most CLLs and in many other malignancies. We have also shown that...
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| Publicado no: | Adv Biol Regul |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7056524/ https://ncbi.nlm.nih.gov/pubmed/31640928 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbior.2019.100669 |
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