Tau, downstream of IDH mut, inhibits the EGFR/NF-kB/TAZ mesenchymal axis, normalizing the vasculature and impairing glioma aggressiveness

Mutant IDH1/2 gliomas represent a more indolent form of cancer. However, how this group of tumors progress, in a microenvironment-dependent manner, is still a pending question. Here we describe that the expression of Tau, a gene classically associated with neurodegenerative diseases, is epigenetical...

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Udgivet i:Sci Transl Med
Main Authors: Gargini, Ricardo, Segura-Collar, Berta, Herránz, Beatriz, Garcia-Escudero, Vega, Romero-Bravo, Andrés, Núñez, Felipe J, García-Pérez, Daniel, Gutiérrez-Guamán, Jacqueline, Ayuso-Sacido, Angel, Seoane, Joan, Pérez-Núñez, Angel, Sepúlveda-Sánchez, Juan M., Hernández-Laín, Aurelio, Castro, María G., García-Escudero, Ramón, Ávila, Jesús, Sánchez-Gómez, Pilar
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7055928/
https://ncbi.nlm.nih.gov/pubmed/31969485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aax1501
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