Small molecule-directed specification of sclerotome-like chondroprogenitors and induction of a somitic chondrogenesis program from embryonic stem cells

Pluripotent embryonic stem cells (ESCs) generate rostral paraxial mesoderm-like progeny in 5-6 days of differentiation induced by Wnt3a and Noggin (Nog). We report that canonical Wnt signaling introduced either by forced expression of activated β-catenin, or the small-molecule inhibitor of Gsk3, CHI...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Development
Hauptverfasser: Zhao, Jiangang, Li, Songhui, Trilok, Suprita, Tanaka, Makoto, Jokubaitis-Jameson, Vanta, Wang, Bei, Niwa, Hitoshi, Nakayama, Naoki
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Company of Biologists 2014
Schlagworte:
Stem Cells and Regeneration
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7055718/
https://ncbi.nlm.nih.gov/pubmed/25294938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.105981
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