Engineering γδT cells limits tonic signaling associated with chimeric antigen receptors

Despite the benefits of chimeric antigen receptor (CAR)-T cell therapies against lymphoid malignancies, responses in solid tumors have been more limited, and off target toxicities more marked. Amongst the possible design limitations of CAR-T for cancer are unwanted tonic signaling and off target act...

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Detalhes bibliográficos
Publicado no:Sci Signal
Main Authors: Fisher, Jonathan, Sharma, Roshan, Don, Dilu Wisidagamage, Barisa, Marta, Hurtado, Marina Olle, Abramowski, Pierre, Porter, Lucy, Day, William, Borea, Roberto, Inglott, Sarah, Anderson, John, Pe’er, Dana
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7055420/
https://ncbi.nlm.nih.gov/pubmed/31506382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aax1872
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