A novel α-fetoprotein-derived helper T-lymphocyte epitope with strong immunogenicity in patients with hepatocellular carcinoma

α-Fetoprotein (AFP) is considered a good target for immunotherapy strategies against hepatocellular carcinoma (HCC); however, no immunodominant AFP-derived MHC class II-restricted helper T-lymphocyte (HTL) epitope has been reported. Therefore, we identified novel AFP-derived HTL epitopes possessing...

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Pubblicato in:Sci Rep
Autori principali: Tamai, Toshikatsu, Mizukoshi, Eishiro, Kumagai, Masashi, Terashima, Takeshi, Iida, Noriho, Kitahara, Masaaki, Shimakami, Tetsuro, Kitamura, Kazuya, Arai, Kuniaki, Yamashita, Taro, Sakai, Yoshio, Yamashita, Tatsuya, Honda, Masao, Fushimi, Kazumi, Kaneko, Shuichi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7055302/
https://ncbi.nlm.nih.gov/pubmed/32132566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-60843-4
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