Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension

Pulmonary arterial hypertension (PAH) is a severe disorder of lung vasculature that causes right heart failure. Homoeostatic effects of flow-activated transcription factor Krüppel-like factor 2 (KLF2) are compromised in PAH. Here, we show that KLF2-induced exosomal microRNAs, miR-181a-5p and miR-324...

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Publicat a:Nat Commun
Autors principals: Sindi, Hebah A., Russomanno, Giusy, Satta, Sandro, Abdul-Salam, Vahitha B., Jo, Kyeong Beom, Qazi-Chaudhry, Basma, Ainscough, Alexander J., Szulcek, Robert, Jan Bogaard, Harm, Morgan, Claire C., Pullamsetti, Soni S., Alzaydi, Mai M., Rhodes, Christopher J., Piva, Roberto, Eichstaedt, Christina A., Grünig, Ekkehard, Wilkins, Martin R., Wojciak-Stothard, Beata
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7055281/
https://ncbi.nlm.nih.gov/pubmed/32132543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14966-x
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