Microarray analyses reveal strain-specific antibody responses to Plasmodium falciparum apical membrane antigen 1 variants following natural infection and vaccination

Vaccines based on Plasmodium falciparum apical membrane antigen 1 (AMA1) have failed due to extensive polymorphism in AMA1. To assess the strain-specificity of antibody responses to malaria infection and AMA1 vaccination, we designed protein and peptide microarrays representing hundreds of unique AM...

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Udgivet i:Sci Rep
Main Authors: Bailey, Jason A., Berry, Andrea A., Travassos, Mark A., Ouattara, Amed, Boudova, Sarah, Dotsey, Emmanuel Y., Pike, Andrew, Jacob, Christopher G., Adams, Matthew, Tan, John C., Bannen, Ryan M., Patel, Jigar J., Pablo, Jozelyn, Nakajima, Rie, Jasinskas, Algis, Dutta, Sheetij, Takala-Harrison, Shannon, Lyke, Kirsten E., Laurens, Matthew B., Niangaly, Amadou, Coulibaly, Drissa, Kouriba, Bourema, Doumbo, Ogobara K., Thera, Mahamadou A., Felgner, Philip L., Plowe, Christopher V.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7054363/
https://ncbi.nlm.nih.gov/pubmed/32127565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-60551-z
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