Hypothermia but not NMDA receptor antagonism protects against stroke induced by distal middle cerebral arterial occlusion in mice

Excitotoxicity mediated by the N-methyl-D-aspartate receptor (NMDAR) is believed to be a primary mechanism of neuronal injury following stroke. Thus, many drugs and therapeutic peptides were developed to inhibit either the NMDAR at the cell surface or its downstream intracellular death-signaling cas...

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Publicado en:PLoS One
Autores principales: Liu, Che-Wei, Liao, Kate Hsiurong, Tseng, Hsin, Wu, Ching Mei, Chen, Hsiao-Yun, Lai, Ted Weita
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2020
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7053748/
https://ncbi.nlm.nih.gov/pubmed/32126102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0229499
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