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Endocannabinoid degradation inhibitors ameliorate neuronal and synaptic alterations following traumatic brain injury

Our previous work showed that lateral fluid percussion injury to the sensorimotor cortex (SMC) of anesthetized rats increased neuronal synaptic hyperexcitability in layer 5 (L5) neurons in ex vivo brain slices 10 days postinjury. Furthermore, endocannabinoid (EC) degradation inhibition via intraperi...

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Foilsithe in:J Neurophysiol
Main Authors: Fucich, Elizabeth A., Stielper, Zachary F., Cancienne, Heather L., Edwards, Scott, Gilpin, Nicholas W., Molina, Patricia E., Middleton, Jason W.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Physiological Society 2020
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7052644/
https://ncbi.nlm.nih.gov/pubmed/31913777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/jn.00570.2019
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