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Differential regulation of mTORC1 activation by leucine and β-hydroxy-β-methylbutyrate in skeletal muscle of neonatal pigs

Leucine (Leu) and its metabolite β-hydroxy-β-methylbutyrate (HMB) stimulate mechanistic target of rapamycin (mTOR) complex 1 (mTORC1)-dependent protein synthesis in the skeletal muscle of neonatal pigs. This study aimed to determine whether HMB and Leu utilize common nutrient-sensing mechanisms to a...

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Publicat a:J Appl Physiol (1985)
Autors principals: Suryawan, Agus, Rudar, Marko, Fiorotto, Marta L., Davis, Teresa A.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2020
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7052585/
https://ncbi.nlm.nih.gov/pubmed/31944890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/japplphysiol.00332.2019
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