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Rapid hepatic metabolism blunts the endocrine action of portally infused GLP-1 in male rats
Glucagon-like peptide-1 (GLP-1) is an enteral peptide that contributes to the incretin effect. GLP-1 action is typically described as endocrine, but this mechanism has been questioned because rapid inactivation in the circulation by dipeptidylpeptidase 4 (DPP4) results in a short half-life, limiting...
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| Publicat a: | Am J Physiol Endocrinol Metab |
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| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Physiological Society
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7052580/ https://ncbi.nlm.nih.gov/pubmed/31743041 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00298.2019 |
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