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Extending the Detection Limit in Fragment Screening of Proteins using Reverse Micelle Encapsulation
Detection of very weak (K(d) > 10 mM) interactions of proteins with small molecules has been elusive. This is particularly important for fragment-based drug discovery where it is suspected that the majority of potentially useful fragments will be invisible to current screening methodologies. We d...
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| Pubblicato in: | ACS Chem Biol |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7051832/ https://ncbi.nlm.nih.gov/pubmed/31550881 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00537 |
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