Lactate dehydrogenase: a marker of diminished antitumor immunity

Lactate dehydrogenase (LDH) levels are inversely related with response to checkpoint inhibitors. Elevated LDH levels are the product of enhanced glycolytic activity of the tumor and tumor necrosis due to hypoxia, the latter being associated with high tumor burden. In this review, we elucidate the ef...

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Detalhes bibliográficos
Publicado no:Oncoimmunology
Main Authors: Van Wilpe, Sandra, Koornstra, Rutger, Den Brok, Martijn, De Groot, Jan Willem, Blank, Christian, De Vries, Jolanda, Gerritsen, Winald, Mehra, Niven
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2020
Assuntos:
Review
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7051189/
https://ncbi.nlm.nih.gov/pubmed/32158624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2020.1731942
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