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The biochemical basis of microRNA targeting efficacy

MicroRNAs (miRNAs) act within Argonaute proteins to guide repression of messenger RNA targets. Although various approaches have provided insight into target recognition, the sparsity of miRNA–target affinity measurements has limited understanding and prediction of targeting efficacy. Here, we adapte...

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Detalhes bibliográficos
Publicado no:Science
Main Authors: McGeary, Sean E., Lin, Kathy S., Shi, Charlie Y., Pham, Thy M., Bisaria, Namita, Kelley, Gina M., Bartel, David P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7051167/
https://ncbi.nlm.nih.gov/pubmed/31806698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aav1741
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