Noncoding SNPs influence a distinct phase of Polycomb silencing to destabilize long-term epigenetic memory at Arabidopsis FLC

In Arabidopsis thaliana, the cold-induced epigenetic regulation of FLOWERING LOCUS C (FLC) involves distinct phases of Polycomb repressive complex 2 (PRC2) silencing. During cold, a PHD–PRC2 complex metastably and digitally nucleates H3K27me3 within FLC. On return to warm, PHD–PRC2 spreads across th...

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Publicado en:Genes Dev
Autores principales: Qüesta, Julia I., Antoniou-Kourounioti, Rea L., Rosa, Stefanie, Li, Peijin, Duncan, Susan, Whittaker, Charles, Howard, Martin, Dean, Caroline
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2020
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Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7050481/
https://ncbi.nlm.nih.gov/pubmed/32001513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.333245.119
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