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Molecular basis of Bacillus subtilis ATCC6633 self-resistance to the phosphono-oligopeptide antibiotic rhizocticin
Rhizocticins are phosphono-oligopeptide antibiotics that contain a toxic C-terminal (Z)-L-2-amino-5-phosphono-3-pentenoic acid (APPA) moiety. APPA is an irreversible inhibitor of threonine synthase (ThrC), a pyridoxal 5’-phosphate (PLP)-dependent enzyme that catalyzes the conversion of O-phospho-L-h...
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| Pubblicato in: | ACS Chem Biol |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7050208/ https://ncbi.nlm.nih.gov/pubmed/30830751 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00030 |
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