Molecular basis of Bacillus subtilis ATCC6633 self-resistance to the phosphono-oligopeptide antibiotic rhizocticin

Rhizocticins are phosphono-oligopeptide antibiotics that contain a toxic C-terminal (Z)-L-2-amino-5-phosphono-3-pentenoic acid (APPA) moiety. APPA is an irreversible inhibitor of threonine synthase (ThrC), a pyridoxal 5’-phosphate (PLP)-dependent enzyme that catalyzes the conversion of O-phospho-L-h...

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Bibliographic Details
Published in:ACS Chem Biol
Main Authors: Petronikolou, Nektaria, Ortega, Manuel A., Borisova, Svetlana A., Nair, Satish K., Metcalf, William W.
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7050208/
https://ncbi.nlm.nih.gov/pubmed/30830751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00030
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