Guidance Document: Validation of a High-Performance Liquid Chromatography-Tandem Mass Spectrometry Immunopeptidomics Assay for the Identification of HLA Class I Ligands Suitable for Pharmaceutical Therapies

For more than two decades naturally presented, human leukocyte antigen (HLA)-restricted peptides (immunopeptidome) have been eluted and sequenced using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Since, identified disease-associated HLA ligands have been characterized and evaluated as...

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Detalhes bibliográficos
Publicado no:Mol Cell Proteomics
Main Authors: Ghosh, Michael, Gauger, Marion, Marcu, Ana, Nelde, Annika, Denk, Monika, Schuster, Heiko, Rammensee, Hans-Georg, Stevanović, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Commentary
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7050110/
https://ncbi.nlm.nih.gov/pubmed/31937595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.C119.001652
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