PIEZO1 activation delays erythroid differentiation of normal and hereditary xerocytosis-derived human progenitor cells

Hereditary xerocytosis is a dominantly inherited red cell membrane disorder caused in most cases by gain-of-function mutations in PIEZO1, encoding a mechanosensitive ion channel that translates a mechanic stimulus into calcium influx. We found that PIEZO1 was expressed early in erythroid progenitor...

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Publicat a:Haematologica
Autors principals: Caulier, Alexis, Jankovsky, Nicolas, Demont, Yohann, Ouled-Haddou, Hakim, Demagny, Julien, Guitton, Corinne, Merlusca, Lavinia, Lebon, Delphine, Vong, Pascal, Aubry, Aurélien, Lahary, Agnès, Rose, Christian, Gréaume, Sandrine, Cardon, Emilie, Platon, Jessica, Ouadid-Ahidouch, Halima, Rochette, Jacques, Marolleau, Jean-Pierre, Picard, Véronique, Garçon, Loïc
Format: Artigo
Idioma:Inglês
Publicat: Ferrata Storti Foundation 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7049340/
https://ncbi.nlm.nih.gov/pubmed/31413092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2019.218503
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