Structural analysis of a trimeric assembly of the mitochondrial dynamin-like GTPase Mgm1

The fusion of inner mitochondrial membranes requires dynamin-like GTPases, Mgm1 in yeast and OPA1 in mammals, but how they mediate membrane fusion is poorly understood. Here, we determined the crystal structure of Saccharomyces cerevisiae short Mgm1 (s-Mgm1) in complex with GDP. It revealed an N-ter...

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Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Yan, Liming, Qi, Yuanbo, Ricketson, Derek, Li, Lei, Subramanian, Kelly, Zhao, Jinghua, Yu, Caiting, Wu, Lijie, Sarsam, Reta, Wong, Melissa, Lou, Zhiyong, Rao, Zihe, Nunnari, Jodi, Hu, Junjie
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2020
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7049166/
https://ncbi.nlm.nih.gov/pubmed/32041880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1919116117
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