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Erk1/2 inactivation promotes a rapid redistribution of COP1 and degradation of COP1 substrates

Anthrax lethal toxin (LT) is a protease virulence factor produced by Bacillus anthracis that is required for its pathogenicity. LT treatment causes a rapid degradation of c-Jun protein that follows inactivation of the MEK1/2-Erk1/2 signaling pathway. Here we identify COP1 as the ubiquitin E3 ligase...

詳細記述

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書誌詳細
出版年:Proc Natl Acad Sci U S A
主要な著者: Ouyang, Weiming, Guo, Pengfei, Takeda, Kazuyo, Fu, Qiong, Fang, Hui, Frucht, David M.
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7049164/
https://ncbi.nlm.nih.gov/pubmed/32041890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1913698117
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