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Erk1/2 inactivation promotes a rapid redistribution of COP1 and degradation of COP1 substrates
Anthrax lethal toxin (LT) is a protease virulence factor produced by Bacillus anthracis that is required for its pathogenicity. LT treatment causes a rapid degradation of c-Jun protein that follows inactivation of the MEK1/2-Erk1/2 signaling pathway. Here we identify COP1 as the ubiquitin E3 ligase...
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| 出版年: | Proc Natl Acad Sci U S A |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2020
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7049164/ https://ncbi.nlm.nih.gov/pubmed/32041890 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1913698117 |
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