Impaired lipid metabolism by age-dependent DNA methylation alterations accelerates aging

Epigenetic alterations and metabolic dysfunction are two hallmarks of aging. However, the mechanism of how their interaction regulates aging, particularly in mammals, remains largely unknown. Here we show ELOVL fatty acid elongase 2 (Elovl2), a gene whose epigenetic alterations are most highly corre...

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書誌詳細
出版年:Proc Natl Acad Sci U S A
主要な著者: Li, Xin, Wang, Jiaqiang, Wang, Leyun, Feng, Guihai, Li, Gen, Yu, Meixin, Li, Yufei, Liu, Chao, Yuan, Xuewei, Zang, Guangxi, Li, Zhihuan, Zhao, Ling, Ouyang, Hong, Quan, Qingli, Wang, Guangyu, Zhang, Charlotte, Li, Oulan, Xiang, Junkai, Zhu, Jian-Kang, Li, Wei, Zhou, Qi, Zhang, Kang
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2020
主題:
Biological Sciences
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7049154/
https://ncbi.nlm.nih.gov/pubmed/32029582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1919403117
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