Tumor Mutational Burden From Tumor-Only Sequencing Compared With Germline Subtraction From Paired Tumor and Normal Specimens

IMPORTANCE: Tumor mutation burden (TMB) is an emerging factor associated with survival with immunotherapy. When tumor-normal pairs are available, TMB is determined by calculating the difference between somatic and germline sequences. In the case of commonly used tumor-only sequencing, additional ste...

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Detalhes bibliográficos
Publicado no:JAMA Netw Open
Main Authors: Parikh, Kaushal, Huether, Robert, White, Kevin, Hoskinson, Derick, Beaubier, Nike, Dong, Haidong, Adjei, Alex A., Mansfield, Aaron S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Medical Association 2020
Assuntos:
Original Investigation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7049088/
https://ncbi.nlm.nih.gov/pubmed/32108894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamanetworkopen.2020.0202
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