Blockade of OX40/OX40L pathway combined with ethylene-carbodiimide-fixed donor splenocytes induces donor-specific allograft tolerance in presensitized recipients

BACKGROUND: Memory T cells (Tms) are the major barrier preventing long-term allograft survival in presensitized transplant recipients. The OX40/OX40L pathway is important in the induction and maintenance of Tms. METHODS: In this study, we added anti-OX40L mAb to ethylene-carbodiimide-fixed donor spl...

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Publicat a:Ann Transl Med
Autors principals: Lai, Xingqiang, Yao, Zhongpeng, Ning, Fen, Zhang, Lei, Fang, Jiali, Li, Guanghui, Xu, Lu, Xiong, Yunyi, Liu, Luhao, Chen, Rongxin, Ma, Junjie, Chen, Zheng
Format: Artigo
Idioma:Inglês
Publicat: AME Publishing Company 2020
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7048988/
https://ncbi.nlm.nih.gov/pubmed/32175377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21037/atm.2019.12.146
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