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miR-142 induces accumulation of reactive oxygen species (ROS) by inhibiting pexophagy in aged bone marrow mesenchymal stem cells

Elevation of the levels of reactive oxygen species (ROS) is a major tissue-degenerative phenomenon involved in aging and aging-related diseases. The detailed mechanisms underlying aging-related ROS generation remain unclear. Presently, the expression of microRNA (miR)-142-5p was significantly upregu...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Houri, Kei, Mori, Tatsufumi, Onodera, Yuta, Tsujimoto, Takatoshi, Takehara, Toshiyuki, Nakao, Shinichi, Teramura, Takeshi, Fukuda, Kanji
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7048811/
https://ncbi.nlm.nih.gov/pubmed/32111926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-60346-2
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