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Adeno-Associated Virus Serotype-Specific Inverted Terminal Repeat Sequence Role in Vector Transgene Expression

Adeno-associated viral vectors have been successfully used in laboratory and clinical settings for efficient gene delivery. In these vectors, 96% of the adeno-associated virus (AAV) genome is replaced with a gene cassette of interest, leaving only the 145 bp inverted terminal repeat (ITR) sequences....

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Hum Gene Ther
Hauptverfasser: Earley, Lauriel F., Conatser, Laura M., Lue, Victoria M., Dobbins, Amanda L., Li, Chengwen, Hirsch, Matthew L., Samulski, R. Jude
Format: Artigo
Sprache:Inglês
Veröffentlicht: Mary Ann Liebert, Inc., publishers 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7047122/
https://ncbi.nlm.nih.gov/pubmed/31914802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2019.274
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