Mosaic chromosome Y loss is associated with alterations in blood cell counts in UK Biobank men

Mosaic loss of Y chromosome (mLOY) is the most frequently detected somatic copy number alteration in leukocytes of men. In this study, we investigate blood cell counts as a potential mechanism linking mLOY to disease risk in 206,353 UK males. Associations between mLOY, detected by genotyping arrays,...

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Pubblicato in:Sci Rep
Autori principali: Lin, Shu-Hong, Loftfield, Erikka, Sampson, Josh N., Zhou, Weiyin, Yeager, Meredith, Freedman, Neal D., Chanock, Stephen J., Machiela, Mitchell J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7046668/
https://ncbi.nlm.nih.gov/pubmed/32108144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-59963-8
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