Gene therapy conversion of striatal astrocytes into GABAergic neurons in mouse models of Huntington’s disease

Huntington’s disease (HD) is caused by Huntingtin (Htt) gene mutation resulting in the loss of striatal GABAergic neurons and motor functional deficits. We report here an in vivo cell conversion technology to reprogram striatal astrocytes into GABAergic neurons in both R6/2 and YAC128 HD mouse model...

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Publicat a:Nat Commun
Autors principals: Wu, Zheng, Parry, Matthew, Hou, Xiao-Yi, Liu, Min-Hui, Wang, Hui, Cain, Rachel, Pei, Zi-Fei, Chen, Yu-Chen, Guo, Zi-Yuan, Abhijeet, Sambangi, Chen, Gong
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7046613/
https://ncbi.nlm.nih.gov/pubmed/32107381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14855-3
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