SGLT2 Inhibitor–Induced Sympathoinhibition: A Novel Mechanism for Cardiorenal Protection

Recent clinical trial data suggest a cardiorenal protective effect of sodium glucose cotransporter 2 (SGLT2) inhibition. We demonstrate that chemical denervation in neurogenic hypertensive Schlager (BPH/2J) mice reduced blood pressure, improved glucose homeostasis, and reduced renal SGLT2 protein ex...

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Dettagli Bibliografici
Pubblicato in:JACC Basic Transl Sci
Autori principali: Herat, Lakshini Y., Magno, Aaron L., Rudnicka, Caroline, Hricova, Jana, Carnagarin, Revathy, Ward, Natalie C., Arcambal, Angelique, Kiuchi, Marcio G., Head, Geoff A., Schlaich, Markus P., Matthews, Vance B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2020
Soggetti:
PRECLINICAL RESEARCH
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7046513/
https://ncbi.nlm.nih.gov/pubmed/32140623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacbts.2019.11.007
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