B cells infected with Type 2 Epstein-Barr virus (EBV) have increased NFATc1/NFATc2 activity and enhanced lytic gene expression in comparison to Type 1 EBV infection

Humans are infected with two distinct strains (Type 1 (T1) and Type 2 (T2)) of Epstein-Barr virus (EBV) that differ substantially in their EBNA2 and EBNA 3A/B/C latency genes and the ability to transform B cells in vitro. While most T1 EBV strains contain the “prototype” form of the BZLF1 immediate-...

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Udgivet i:PLoS Pathog
Main Authors: Romero-Masters, James C., Huebner, Shane M., Ohashi, Makoto, Bristol, Jillian A., Benner, Bayleigh E., Barlow, Elizabeth A., Turk, Gail L., Nelson, Scott E., Baiu, Dana C., Van Sciver, Nicholas, Ranheim, Erik A., Gumperz, Jenny, Sherer, Nathan M., Farrell, Paul J., Johannsen, Eric C., Kenney, Shannon C.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7046292/
https://ncbi.nlm.nih.gov/pubmed/32059024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008365
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