Synthesis and evaluation of 6-([(11)C]methyl(4-(pyridin-2-yl)thiazol-2-yl)amino)benzo[d]thiazol-2(3H)-one for imaging γ-8 dependent transmembrane AMPA receptor regulatory protein by PET

Transmembrane AMPA receptor regulatory proteins (TARPs) are a recently discovered family of proteins that modulate AMPA receptors activity. Based on a potent and selective TARP subtype γ−8 antagonist, 6-(methyl(4-(pyridin-2-yl)thiazol-2-yl)amino)benzo[d]thiazol-2(3H)-one (compound 9), we perform the...

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Udgivet i:Bioorg Med Chem Lett
Main Authors: Yu, Qingzhen, Kumata, Katsushi, Li, Hua, Zhang, Yiding, Chen, Zhen, Zhang, Xiaofei, Shao, Tuo, Hatori, Akiko, Yamasaki, Tomoteru, Xie, Lin, Hu, Kuan, Wang, Gangqiang, Josephson, Lee, Sun, Shaofa, Zhang, Ming-Rong, Liang, Steven H.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7045276/
https://ncbi.nlm.nih.gov/pubmed/31879207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2019.126879
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