Oral typhoid vaccine Ty21a elicits antigen-specific resident memory CD4(+) T cells in the human terminal ileum lamina propria and epithelial compartments

BACKGROUND: Salmonella enterica serovar Typhi (S. Typhi) is a highly invasive bacterium that infects the human intestinal mucosa and causes ~ 11.9–20.6 million infections and ~ 130,000–223,000 deaths annually worldwide. Oral typhoid vaccine Ty21a confers a moderate level of long-lived protection (5–...

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Bibliographic Details
Published in:J Transl Med
Main Authors: Booth, Jayaum S., Goldberg, Eric, Barnes, Robin S., Greenwald, Bruce D., Sztein, Marcelo B.
Format: Artigo
Language:Inglês
Published: BioMed Central 2020
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7043047/
https://ncbi.nlm.nih.gov/pubmed/32098623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-020-02263-6
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