Phosphorylated ERK1/2 in CD4 T cells is associated with acute GVHD in allogeneic hematopoietic stem cell transplantation

To diagnose graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is sometimes difficult. We showed previously that MEK inhibitors selectively suppress murine GVHD while retaining antiviral and antitumor immunity. Here, we asked whether the RAS/MEK/ERK...

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Bibliografiske detaljer
Udgivet i:Blood Adv
Main Authors: Itamura, Hidekazu, Shindo, Takero, Yoshioka, Satoshi, Ishikawa, Takayuki, Kimura, Shinya
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2020
Fag:
Transplantation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7042985/
https://ncbi.nlm.nih.gov/pubmed/32078679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019000343
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