Predictive Accuracy of a Polygenic Risk Score–Enhanced Prediction Model vs a Clinical Risk Score for Coronary Artery Disease

IMPORTANCE: The incremental value of polygenic risk scores in addition to well-established risk prediction models for coronary artery disease (CAD) is uncertain. OBJECTIVE: To examine whether a polygenic risk score for CAD improves risk prediction beyond pooled cohort equations. DESIGN, SETTING, AND...

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Dettagli Bibliografici
Pubblicato in:JAMA
Autori principali: Elliott, Joshua, Bodinier, Barbara, Bond, Tom A., Chadeau-Hyam, Marc, Evangelou, Evangelos, Moons, Karel G. M., Dehghan, Abbas, Muller, David C., Elliott, Paul, Tzoulaki, Ioanna
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Medical Association 2020
Soggetti:
Original Investigation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7042853/
https://ncbi.nlm.nih.gov/pubmed/32068818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jama.2019.22241
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