Predictive Accuracy of a Polygenic Risk Score Compared With a Clinical Risk Score for Incident Coronary Heart Disease

IMPORTANCE: Polygenic risk scores comprising millions of single-nucleotide polymorphisms (SNPs) could be useful for population-wide coronary heart disease (CHD) screening. OBJECTIVE: To determine whether a polygenic risk score improves prediction of CHD compared with a guideline-recommended clinical...

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Détails bibliographiques
Publié dans:JAMA
Auteurs principaux: Mosley, Jonathan D., Gupta, Deepak K., Tan, Jingyi, Yao, Jie, Wells, Quinn S., Shaffer, Christian M., Kundu, Suman, Robinson-Cohen, Cassianne, Psaty, Bruce M., Rich, Stephen S., Post, Wendy S., Guo, Xiuqing, Rotter, Jerome I, Roden, Dan M., Gerszten, Robert E., Wang, Thomas J.
Format: Artigo
Langue:Inglês
Publié: American Medical Association 2020
Sujets:
Original Investigation
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7042849/
https://ncbi.nlm.nih.gov/pubmed/32068817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jama.2019.21782
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