Combination of chemotherapy and PD-1 blockade induces T cell responses to tumor non-mutated neoantigens

Here, we developed an unbiased, functional target-discovery platform to identify immunogenic proteins from primary non-small cell lung cancer (NSCLC) cells that had been induced to apoptosis by cisplatin (CDDP) treatment in vitro, as compared with their live counterparts. Among the multitude of prot...

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Veröffentlicht in:Commun Biol
Hauptverfasser: Grimaldi, Alessio, Cammarata, Ilenia, Martire, Carmela, Focaccetti, Chiara, Piconese, Silvia, Buccilli, Marta, Mancone, Carmine, Buzzacchino, Federica, Berrios, Julio Rodrigo Giron, D’Alessandris, Nicoletta, Tomao, Silverio, Giangaspero, Felice, Paroli, Marino, Caccavale, Rosalba, Spinelli, Gian Paolo, Girelli, Gabriella, Peruzzi, Giovanna, Nisticò, Paola, Spada, Sheila, Panetta, Mariangela, Letizia Cecere, Fabiana, Visca, Paolo, Facciolo, Francesco, Longo, Flavia, Barnaba, Vincenzo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7042341/
https://ncbi.nlm.nih.gov/pubmed/32099064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-0811-x
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