CSF1R inhibitor PLX5622 and environmental enrichment additively improve metabolic outcomes in middle-aged female mice

As the elderly population grows, chronic metabolic dysfunction including obesity and diabetes are becoming increasingly common comorbidities. Hypothalamic inflammation through CNS resident microglia serves as a common pathway between developing obesity and developing systemic aging pathologies. Desp...

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Bibliographische Detailangaben
Veröffentlicht in:Aging (Albany NY)
Hauptverfasser: Ali, Seemaab, Mansour, Anthony G., Huang, Wei, Queen, Nicholas J., Mo, Xiaokui, Anderson, Jacqueline M., Hassan II, Quais N., Patel, Ripal S., Wilkins, Ryan K., Caligiuri, Michael A., Cao, Lei
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals 2020
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7041757/
https://ncbi.nlm.nih.gov/pubmed/32007953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.102724
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