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KRAS G12C Game of Thrones, which direct KRAS inhibitor will claim the iron throne?
Mutations in Kirsten rat sarcoma viral oncogene homolog (KRAS) are among the most common aberrations in cancer, including non-small cell lung cancer (NSCLC). The lack of an ideal small molecule binding pocket in KRAS protein and its high affinity towards the abundance of cellular guanosine triphosph...
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| Опубликовано в: : | Cancer Treat Rev |
|---|---|
| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2020
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7041424/ https://ncbi.nlm.nih.gov/pubmed/32014824 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ctrv.2020.101974 |
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