A Randomized, Double-Blinded, Placebo-Controlled, Dose-Escalation Phase 1 Study of Aerosolized Pirfenidone Delivered via the PARI Investigational eFlow Nebulizer in Volunteers and Patients with Idiopathic Pulmonary Fibrosis

Background: This clinical trial evaluated the pharmacokinetics and safety/tolerability of inhaled pirfenidone solution in volunteers and patients with idiopathic pulmonary fibrosis (IPF). Methods: Forty-four adults in six cohorts consented to receive single doses of a 12.5 mg/mL pirfenidone solution...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Aerosol Med Pulm Drug Deliv
Prif Awduron: Khoo, Jun Keng, Montgomery, A. Bruce, Otto, Kelly L., Surber, Mark, Faggian, Jessica, Lickliter, Jason D., Glaspole, Ian
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Mary Ann Liebert, Inc., publishers 2020
Pynciau:
Original Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7041323/
https://ncbi.nlm.nih.gov/pubmed/30698487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/jamp.2018.1507
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