Reduced doses of dabrafenib and trametinib combination therapy for BRAF V600E-mutant non-small cell lung cancer prevent rhabdomyolysis and maintain tumor shrinkage: a case report

BACKGROUND: A BRAF V600E mutation is found as driver oncogene in patients with non-small cell lung cancer. Although combined treatment with dabrafenib and trametinib is highly effective, the efficacy of reduced doses of the drugs in combination therapy has not yet been reported. CASE PRESENTATION: A...

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Veröffentlicht in:BMC Cancer
Hauptverfasser: Adachi, Yuta, Yanagimura, Naohiro, Suzuki, Chiaki, Ootani, Sakiko, Tanimoto, Azusa, Nishiyama, Akihiro, Yamashita, Kaname, Ohtsubo, Koushiro, Takeuchi, Shinji, Yano, Seiji
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2020
Schlagworte:
Case Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7041078/
https://ncbi.nlm.nih.gov/pubmed/32093631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-020-6626-9
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