Droplet-based digital antibiotic susceptibility screen reveals single-cell clonal heteroresistance in an isogenic bacterial population

Since antibiotic resistance is a major threat to global health, recent observations that the traditional test of minimum inhibitory concentration (MIC) is not informative enough to guide effective antibiotic treatment are alarming. Bacterial heteroresistance, in which seemingly susceptible isogenic...

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Pubblicato in:Sci Rep
Autori principali: Scheler, Ott, Makuch, Karol, Debski, Pawel R., Horka, Michal, Ruszczak, Artur, Pacocha, Natalia, Sozański, Krzysztof, Smolander, Olli-Pekka, Postek, Witold, Garstecki, Piotr
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7039976/
https://ncbi.nlm.nih.gov/pubmed/32094499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-60381-z
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