Suppressing STAT5 signaling affects osteosarcoma growth and stemness

Osteosarcoma (OS) is the most common primary bone tumor that primarily affects children and adolescents. Studies suggested that dysregulation JAK/STAT signaling promotes the development of OS. Cells treated with pimozide, a STAT5 inhibitor suppressed proliferation and colony formation and induced su...

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Pubblicato in:Cell Death Dis
Autori principali: Subramaniam, Dharmalingam, Angulo, Pablo, Ponnurangam, Sivapriya, Dandawate, Prasad, Ramamoorthy, Prabhu, Srinivasan, Pugazhendhi, Iwakuma, Tomoo, Weir, Scott J., Chastain, Katherine, Anant, Shrikant
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7039889/
https://ncbi.nlm.nih.gov/pubmed/32094348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2335-1
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